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  • Pathology Outlines - Atypical meningioma
    The image shows an atypical meningioma with small cell change, characterized by reduced cytoplasm and increased N C ratio in these regions These regions may resemble lymphoplasmacytic inflammation on low power but on high power show nuclei that are similar to adjacent tumor cells Comment Here Reference: Atypical meningioma
  • Pathology Outlines - WHO grading of meningiomas
    Anaplastic meningioma Additional references J Neuropathol Exp Neurol 2016;75:44 , Brain Pathol 2015;25:266 , Acta Neuropathol 2018;136:975 , Neuro Oncol 2017;19:535 , Acta Neuropathol 2018;135:955 , WHO Classification of Tumors Editorial Board: Central Nervous System Tumours, 5th Edition, 2022
  • Pathology Outlines - Ectopic meningioma
    Like primary intracranial meningioma, tumor grade and extent of surgical resection are the most important prognostic factors for ectopic meningioma In general, ectopic meningioma of the head and neck tends to show a higher recurrence rate due to complex anatomy and difficulty in obtaining complete surgical resection ( Ear Nose Throat J 2022;101:NP383 )
  • Pathology Outlines - Clear cell meningioma
    Usually lack atypical meningioma features such as small cell change, hypercellularity and prominent nucleoli Necrosis is rare May not display any characteristic meningioma features (whorls, psammoma bodies, intranuclear inclusions) References: Acta Neuropathol 2021;141:281, Brain Pathol 2018;28:466
  • Pathology Outlines - Chordoid meningioma
    Chordoid meningioma is a histological subtype of meningioma characterized by cords or trabeculae of epithelioid (or spindle) cells embedded in a mucin rich stroma and resembling chordoma It is classified as CNS WHO grade 2, regardless of the presence of worrisome histological features (mitoses, spontaneous necrosis, brain invasion)
  • Pathology Outlines - Papillary meningioma
    19 year old man with spinal papillary meningioma (Acta Neurochir (Wien) 2000;142:703) 25 year old woman with jugular foramen papillary meningioma (Brain Tumor Pathol 2004;21:143) 29 year old woman with meningioma with rhabdoid, papillary and clear cell features (Clin Neuropathol 2011;30:291)
  • Pathology Outlines - Solitary fibrous tumor
    (Fibrous) meningioma (closest histologic mimic): STAT6-, EMA+, SSTR2A+ Often shows psammoma bodies calcifications, which are not seen in solitary fibrous tumor Dural Ewing sarcoma: STAT6-, evidence of EWSR1 rearrangement Synovial sarcoma: EMA+, TLE1+, evidence of SS18 rearrangement Malignant peripheral nerve sheath tumor:
  • Pathology Outlines - WHO classification
    Meningioma is considered a single type with 15 subtypes; grading is significantly changed - while chordoid meningioma and clear cell meningioma are still considered CNS WHO grade 2 based on morphology (pending larger studies), the criteria that define atypical (grade 2) or anaplastic (grade 3) meningiomas should be applied to rhabdoid and papillary meningioma instead of assigning grade 3 based
  • Pathology Outlines - SSTR2A
    Independent predictor of improved overall survival and progression free survival in neuroendocrine tumors (NET) (Pancreas 2016;45:1386, Eur J Nucl Med Mol Imaging 2017;44:468, Medicine (Baltimore) 2015;94:e1281)
  • Pathology Outlines - Anaplastic meningioma
    Anaplastic meningioma SSTR2A is the most sensitive and specific marker for meningioma, while STAT6 is the most sensitive and specific marker for solitary fibrous tumor Focal CK AE1 AE3 immunostaining can be found in anaplastic meningioma, whereas metastatic carcinoma features widespread CK AE1 AE3 immunostaining Comment Here





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