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  • Sodium–calcium exchanger 1 is the key molecule for urinary . . .
    The sodium (Na +)-chloride cotransporter (NCC) expressed in the distal convoluted tubule (DCT) is a key molecule regulating urinary Na + and potassium (K +) excretion We previously reported that high-K + load rapidly dephosphorylated NCC and promoted urinary K + excretion in mouse kidneys
  • Distal Convoluted Tubule and Collecting Duct
    On the basolateral membrane, there is also an NCX channel (sodium-calcium antiporter) This is responsible for transporting calcium ions out into the extracellular fluid, and sodium ions into the cell
  • NCX 1 Na Ca exchanger inhibition by antisense . . .
    Renal distal convoluted tubule (DCT) cells express transcripts encoding three alternatively spliced NCX1 isoforms: NACA2 (exons B, C, D), NACA3 (exons B and D), and NACA6 (exons A, C, D)
  • Distal tubule and collecting duct - Deranged Physiology
    Hypokalemic side-effects of frusemide are due to the way potassium and sodium are handled in the distal convoluted tubule As sodium delivery is increased to this tubule, the NCC channel works harder, and more sodium ends up being reabsorbed
  • Physiology of the distal convoluted tubule and collecting duct
    After calcium is shuttled by calbindin to the basolateral surface, Ca2+ is extruded into the peritubular fluid by a sodium calcium exchanger (NCX-2° active transport), which utilises the sodium gradient established from the Na+ K+-ATPase channel, as well as by an ATP dependant calcium hydrogen exchanger
  • Molecular mechanisms altering tubular calcium reabsorption
    The fine tuning of urinary calcium excretion occurs in the distal convoluted and connecting tubule by a transcellular pathway composed of the apical calcium channel TRPV5, the calcium shuttling protein calbindin-D28K and the basolateral proteins PMCA1b and the sodium calcium exchanger, NCX
  • Plasma membrane Ca2+-ATPase and NCX1 Na+ Ca2 . . . - PubMed
    The plasma membrane Ca2+-ATPase (PMCA) and the NCX1 Na+ Ca2+ exchanger regulate intracellular Ca2+ concentrations and mediate Ca2+ efflux in absorptive epithelial cells We characterized the PMCA isoforms and subtypes expressed in mouse distal convoluted tubule (mDCT) cells and Na+ Ca2+ exchanger pr …





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