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  • Dose–Volume Constraints fOr oRganS At risk In Radiotherapy (CORSAIR . . .
    Background: The safe use of radiotherapy (RT) requires compliance with dose volume constraints (DVCs) for organs at risk (OaRs) However, the available recommendations are sometimes conflicting and scattered across a number of different documents
  • Tolerance of Normal Tissue to Therapeutic Radiation
    Brain Radiation necrosis of the brain typically occurs 3 months to several years after radiotherapy (median 1–2 years) (3,7) The original Emami publication estimated a 5% risk of radionecrosis at 5 years with a dose of 60 Gy to one-third of the brain with standard fractionation (3) More recently, QUANTEC conducted an extensive
  • Organs at risk in the brain and their dose-constraints in adults and in . . .
    Because of the small volume of the cochlea a dose–volume ana-lysis is not feasible and only recommendations about the mean dose can be found in literature The recommended dose constraints vary a lot between children and adults, being the limits for pediatric patients significantly low-er
  • UK Consensus on Normal Tissue Dose Constraints for Stereotactic . . .
    For body (extra-cranial) dose constraints, except for the spinal cord canal, a near-point maximum dose volume of 0 5 cm 3 should be used across sites This represents a volume that is both clinically realistic and comparable when calculated across different planning systems
  • Dose tolerance limits and dose volume histogram evaluation for . . .
    We consider SBRT to be small, focused, stereotactically accurate radiation treatments with one to five fractions(2) delivered anywhere in the body This manuscript represents Phase I of a three-phase project to determine SBRT dose toler-ance limits
  • RADIATION DOSE–VOLUME EFFECTS IN THE BRAIN - PMC - PubMed Central (PMC)
    The present report summarizes the dose–volume predictors for the principal late side effects of RT to the brain: radiation necrosis and cognitive deterioration A biopsy is rarely performed to confirm suspected radiation necrosis
  • Dose Tolerances in Brain Metastasis Management
    Using common dose-volume parameters, e g , V12 for single-fraction SRS and V18 for 3-fraction SRS, it would be helpful to have validate models predicting dose tolerance limits for normal brain tissue structure toxicity following biologically equivalent radiosurgical treatments
  • Dose-Volume Tolerance of the Brain and Predictors of Radiation Necrosis . . .
    Radiation necrosis (RN) is the dose-limiting side effect of SRS, but the dose constraints especially for fractionated SRS remain poorly defined We assessed the risk of RN after 3-fraction SRS with a goal to identify specific dose-volume constraints associated with grade 3 or higher RN (G3RN)


















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