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  • NOXA the BCL-2 Family Member behind the Scenes in Cancer Treatment
    NOXA is a critical mediator of stress responses to anticancer drugs This BH3-only protein sets the apoptotic threshold in cancer cells in response to chemotherapies by counteracting the prosurvival BCL-2 family protein MCL-1
  • Noxa: at the tip of the balance between life and death - PMC
    Among all Bcl2 homology domain 3 (BH3)-only proteins known to date, APR PMAIP1 Noxa, albeit showing weak proapoptotic potential on its own, appears to be crucial in fine-tuning cell death decisions by targeting the prosurvival molecule Mcl1 for
  • Noxa: Role in Cancer Pathogenesis and Treatment - PubMed
    Noxa induces apoptosis via p53-dependent and or p53-independent mechanisms While Noxa may play a limited role in apoptosis, it is a crucial player that interacts with several proteins in the apoptosis pathway, highlighting its importance in the pathogenesis and treatment of certain cancers
  • NOXA Definition Meaning | Merriam-Webster Medical
    The meaning of NOXA is something that exerts a harmful effect on the body
  • Noxa | definition of noxa by Medical dictionary
    [MIM*604959] a critical mediator protein involved in apoptosis induced by tumor suppressor p53 and other agents in cells that are exposed to noxious stresses The protein is encoded by the gene Noxa (for damage)
  • Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate . . . - AAAS
    We report a previously unidentified pro-apoptotic gene, Noxa Expression of Noxa induction in primary mouse cells exposed to x-ray irradiation was dependent on p53 Noxa encodes a Bcl-2 homology 3 (BH3)–only member of the Bcl-2 family of proteins; this member contains the BH3 region but not other BH domains
  • BH3-Only Proteins Noxa and Puma Are Key Regulators of Induced Apoptosis
    The pro-apoptotic BH3-only protein Noxa activates multiple death pathways by inhibiting the anti-apoptotic Bcl-2 family protein, Mcl-1, and other protein members leading to Bax and Bak activation and MOMP On the other hand, Puma is induced by p53-dependent and p53-independent apoptotic stimuli in several cancer cell lines
  • Noxa and cancer therapy - PMC - National Center for Biotechnology . . .
    Noxa is a direct transcriptional target of ATF4 and has been reported to be an important mediator of ER stress-induced apoptosis in cancer therapy 52,57 Specifically, Noxa upregulation has been shown to be critical for effective treatment with thapsigargin and tunicamycin in MEFs and HeLa cells, fenretinide in neuroectodermal tumor cells, Eer
  • Noxa: Role in Cancer Pathogenesis and Treatment
    While Noxa may play a limited role in apoptosis, it is a crucial player that interacts with several proteins in the apoptosis pathway, highlighting its importance in the pathogenesis and treatment of certain cancers





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