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  • Spastic Paraplegia 4 - GeneReviews® - NCBI Bookshelf
    Spastic paraplegia 4 (SPG4; also known as SPAST-HSP) is characterized by insidiously progressive bilateral lower-limb gait spasticity More than 50% of affected individuals have some weakness in the legs and impaired vibration sense at the ankles Sphincter disturbances are very common
  • SPAST gene - MedlinePlus
    The SPAST gene provides instructions for producing a protein called spastin, which is a member of the AAA protein family This protein family plays a role in many cellular activities, including regulation of cell components and proteins
  • SPAST Gene - GeneCards | SPAST Protein | SPAST Antibody
    SPAST (Spastin) is a Protein Coding gene Diseases associated with SPAST include Spastic Paraplegia 4, Autosomal Dominant and Hereditary Spastic Paraplegia Among its related pathways are Cell Cycle, Mitotic and Separation of Sister Chromatids
  • Spastin - Wikipedia
    The human gene SPAST codes for the microtubule-severing protein of the same name, commonly known as spastin [5] This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family
  • Hereditary spastic paraplegia 4 | About the Disease | GARD
    Autosomal dominant SPG4 is caused by genetic changes in the SPAST gene Summary Autosomal dominant spastic paraplegia type 4 (Autosomal dominant SPG4) is the most common type of hereditary spastic paraplegia (HSP) inherited in an autosomal dominant manner
  • SPAST Open Access
    Handling editors team for SPAST reports can be accessed here We focus on a range of thrust areas, including: Materials Science Engineering; Micro Nanotechnologies; Computers IT (AI, Machine Learning, Big Data) Wireless Technologies (IoT, Wireless Power Transfer, 5G, LTE) Biosciences, Biomedical, and Biotechnologies; Pharmaceuticals and
  • Entry - *604277 - SPASTIN; SPAST - OMIM
    Using a positional cloning strategy based on the spastic paraplegia-4 (SPG4; 182601) candidate region on chromosome 2p22-p21, Hazan et al (1999) identified a gene encoding a member of the AAA protein family (see 601681), which they named 'spastin' (SPAST)





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