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  • The Effects of Amphetamine and Methamphetamine on the Release . . .
    Recent studies suggest that orexins play a role in drug-induced sensitization and drug-seeking motivation, which occurs through a fair neuro-anatomical specificity (Sharf et al , 2010; Mahler et al , 2012) The effects of orexin-containing nuclei are grounded on their strong connection with reticular NE nuclei
  • Norepinephrine in the Prefrontal Cortex Is Critical for . . .
    Increasing evidence points to a major involvement of cortical areas in addictive mechanisms Noradrenergic transmission in the medial prefrontal cortex (mpFC) has been shown to affect the motor effects of amphetamine, although there is no evidence of its involvement in the rewarding effects of this psychostimulant The present experiments were aimed at investigating the possibility of a
  • Role of brain norepinephrine in the behavioral response to . . .
    Using microinjections of adrenergic antagonist drugs directly into these regions, we have shown that this stress-induced release of NE facilitates a number of anxiety-like behavioral responses that are mediated in these regions, including stress-induced reduction of open-arm exploration on the elevated plus-maze, stress-induced reduction of
  • Alpha2A-Adrenoceptors are Important Modulators of the Effects of
    The behavioral effects of amphetamines have mainly been attributed to changes in dopamine transmission, but they also involve increases in the synaptic concentrations of norepinephrine (NE) α2
  • Adrenaline Rush: The Role of Adrenergic Receptors in . . .
    Psychostimulants, such as cocaine and amphetamines, act primarily through the monoamine neurotransmitters dopamine (DA), norepinephrine, and serotonin Although stimulant addiction research has largely focused on DA, medication development efforts targeting the dopaminergic system have thus far been unsuccessful, leading to alternative strategies aimed at abating stimulant abuse Noradrenergic
  • Adrenaline Rush: The Role of Adrenergic Receptors in . . .
    Relative contribution of adrenergic receptor subtypes to stimulant-induced behaviors Stimulants, such as amphetamines and cocaine, produce behaviors including locomotor activity, conditioned place preference, drug-induced anxiety, drug discrimination, and self-administration Various aspects of these behaviors are subject to control by AR
  • Amphetamine promotes cortical Up state: Role of adrenergic . . .
    Our evidence further suggests that norepinephrine (NE) plays a major role in the effects of d-amphetamine since they were mimicked by the NE reuptake inhibitors tomoxetine and nisoxetine and completely blocked by the α 1 receptor antagonist prazosin The effects of d-amphetamine persisted, however, in the presence of α 2 or β





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