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  • Anticoagulation Reversal Guideline for Adults
    anticoagulant reversal outweighs the risk of thrombosis (either from the reversal agent itself or normalization of coagulation in a patient with underlying thromboembolic risk) These recommendations are meant to serve as general guidelines and should not replace clinical judgment
  • ANTICOAGULANTS: THE GUIDE TO REVERSAL - OHSU
    Reversal of Life Threatening Bleeding: Protamine (works just as well with LMWH as heparin) - if with-in 4 hours of dose: 1 mg of protamine for each 1 mg of enoxaparin or 100 units of dalteparin and tinzaparin Repeat one-half dose of protamine in 4 hours
  • Reversal of direct oral anticoagulants: Highlights from the . . .
    The 2019 guideline from the Anticoagulation Forum provides clear instructions on how to use 2 agents for reversing the effects of direct oral anticoagulants (DOACs): idarucizumab for dabigatran-associated bleeding and andexanet alfa for bleeding associated with rivaroxaban and apixaban
  • Reversal Agents for Direct Oral Anticoagulants (DOACs . . .
    Use of reversal agents should be considered ONLY in severe, life threatening bleeding and where the potential risk of thromboembolism is deemed less than the consequences of continued bleeding DOACs have relatively short half-lives
  • New agents for DOAC reversal: a practical management review
    Andexanet alfa and idarucizumab are targeted reversal agents that can be used in life-threatening or uncontrolled bleeding with rivaroxaban apixaban or dabigatran, respectively They should be used in conjunction with general haemostatic measures and definitive management of the bleeding source
  • Andexxa—An Antidote for Apixaban and Rivaroxaban
    Coagulation factor Xa (recombinant), inactivated-zhzo (andexanet alfa; Andexxa – Portola) has received accelerated approval from the FDA for urgent reversal of the anticoagulant effect of the direct factor Xa inhibitors apixaban (Eliquis) and rivaroxaban (Xarelto)





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