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  • Reducing Hinge Flexibility of CAR-T Cells Prolongs Survival
    This study demonstrated that 2nd-GG CAR exhibits lower flexibility and affinity for the CD19 antigen The 2nd-GG CAR-T cells produced lower levels of cytokines, yet showed similar cytotoxicity to CD19+ tumor cells as 2nd CAR-T cells in vitro However, 2nd-GG CAR-T cells show lower cytokine release in mouse models with moderate and high tumor
  • CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series . . .
    We evaluated 15 patients with severe SLE (8 patients), idiopathic inflammatory myositis (3 patients), or systemic sclerosis (4 patients) who received a single infusion of CD19 chimeric antigen
  • CAR-T design: Elements and their synergistic function
    Chimeric antigen receptor (CAR) T cells use re-engineered cell surface receptors to specifically bind to and lyse oncogenic cells Two clinically approved CAR-T–cell therapies have significant clinical efficacy in treating CD19-positive B cell cancers
  • Reducing Hinge Flexibility of CAR-T Cells Prolongs Survival . . .
    This study demonstrated that 2nd-GG CAR exhibits lower flexibility and affinity for the CD19 antigen The 2nd-GG CAR-T cells produced lower levels of cytokines, yet showed similar cytotoxicity to CD19+ tumor cells as 2nd CAR-T cells in vitro However, 2nd-GG CAR-T cells show lower cytokine release in mouse models with moderate and high tumor
  • CAR T-cell therapy in autoimmune diseases: where are we and . . .
    Beyond the targeting of B cells via CD19, we discuss the advantages and potential pitfalls of targeting plasma cells (B-cell Maturation Antigen or CD138) and other non-immune targets, such as fibroblast activated protein, and of aiming to restore immune homeostasis using CAR T regulatory cells





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