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resolved    音标拼音: [riz'ɑlvd]
a. 下定决心的,断然的

下定决心的,断然的

resolved
adj 1: determined; "she was firmly resolved to be a doctor";
"single-minded in his determination to stop smoking"
[synonym: {single-minded}, {resolved}]
2: explained or answered; "mysteries solved and unsolved;
problems resolved and unresolved" [synonym: {solved}, {resolved}]
[ant: {unresolved}, {unsolved}]

Resolve \Re*solve"\ (r?*z?lv"), v. t. [imp. & p. p. {Resolved}
(-z?lvd"); p. pr. & vb. n. {Resolving}.] [L. resolvere,
resolutum, to untie, loosen, relax, enfeeble; pref. re- re-
solvere to loosen, dissolve: cf. F. r['e]soudare to resolve.
See {Solve}, and cf. {Resolve}, v. i., {Resolute},
{Resolution}.]
1. To separate the component parts of; to reduce to the
constituent elements; -- said of compound substances;
hence, sometimes, to melt, or dissolve.
[1913 Webster]

O, that this too too solid flesh would melt,
Thaw, and resolve itself into a dew! --Shak.
[1913 Webster]

Ye immortal souls, who once were men,
And now resolved to elements again. --Dryden.
[1913 Webster]

2. To reduce to simple or intelligible notions; -- said of
complex ideas or obscure questions; to make clear or
certain; to free from doubt; to disentangle; to unravel;
to explain; hence, to clear up, or dispel, as doubt; as,
to resolve a riddle. "Resolve my doubt." --Shak.
[1913 Webster]

To the resolving whereof we must first know that the
Jews were commanded to divorce an unbelieving
Gentile. --Milton.
[1913 Webster]

3. To cause to perceive or understand; to acquaint; to
inform; to convince; to assure; to make certain.
[1913 Webster]

Sir, be resolved. I must and will come. --Beau. &
Fl.
[1913 Webster]

Resolve me, Reason, which of these is worse,
Want with a full, or with an empty purse? --Pope.
[1913 Webster]

In health, good air, pleasure, riches, I am resolved
it can not be equaled by any region. --Sir W.
Raleigh.
[1913 Webster]

We must be resolved how the law can be pure and
perspicuous, and yet throw a polluted skirt over
these Eleusinian mysteries. --Milton.
[1913 Webster]

4. To determine or decide in purpose; to make ready in mind;
to fix; to settle; as, he was resolved by an unexpected
event.
[1913 Webster]

5. To express, as an opinion or determination, by resolution
and vote; to declare or decide by a formal vote; --
followed by a clause; as, the house resolved (or, it was
resolved by the house) that no money should be apropriated
(or, to appropriate no money).
[1913 Webster]

6. To change or convert by resolution or formal vote; -- used
only reflexively; as, the house resolved itself into a
committee of the whole.
[1913 Webster]

7. (Math.) To solve, as a problem, by enumerating the several
things to be done, in order to obtain what is required; to
find the answer to, or the result of. --Hutton.
[1913 Webster]

8. (Med.) To dispere or scatter; to discuss, as an
inflammation or a tumor.
[1913 Webster]

9. (Mus.) To let the tones (as of a discord) follow their
several tendencies, resulting in a concord.
[1913 Webster]

10. To relax; to lay at ease. [Obs.] --B. Jonson.
[1913 Webster]

{To resolve a nebula}.(Astron.) See {Resolution of a nebula},
under {Resolution}.
[1913 Webster]

Syn: To solve; analyze; unravel; disentangle.
[1913 Webster]


Resolved \Re*solved"\ (r?-z?lvd"), p. p. & a.
Having a fixed purpose; determined; resolute; -- usually
placed after its noun; as, a man resolved to be rich.
[1913 Webster]

That makes him a resolved enemy. --Jer. Taylor.
[1913 Webster]

I am resolved she shall not settle here. --Fielding.
[1913 Webster]


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  • Using a Physiologically Based Pharmacokinetic Absorption Model to . . .
    Virtual BE studies have been conducted using physiologically based pharmacokinetic absorption models (PBPK AMs) to aid the evaluations of generic drug products The aim of the current study is to determine the dissolution boundary for maintaining BE between the test and reference oseltamivir phosphate (OP) drug products using the PBPK AM-based
  • Predicting bioequivalence and developing dissolution bioequivalence . . .
    Bioequivalence (BE) studies support the approval and clinical use of both new and generic drug products Narrow therapeutic index (NTI) drugs have relatively high costs and low success rates of BE evaluation clinical trials as high-risk drugs A physiologically-based pharmacokinetic (PBPK) model can be used to evaluate the BE of two preparations
  • Using a Physiologically Based Pharmacokinetic Absorption Model to . . .
    Virtual BE studies have been conducted using physiologically based pharmacokinetic absorption models (PBPK AMs) to aid the evaluations of generic drug products The aim of the current study is to determine the dissolution boundary for maintaining BE between the test and reference oseltamivir phosphate (OP) drug products using the PBPK AM
  • Using a Physiologically Based Pharmacokinetic Absorption Model to . . .
    Defining a BE safe space with physiologically based biopharmaceutics model (PBBM) allows the establishment of mechanistic in vitro and in vivo relationships (IVIVR) to better understand
  • Predicting bioequivalence and developing dissolution bioequivalence . . .
    A physiologically-based pharmacokinetic (PBPK) model can be used to evaluate the BE of two preparations Methods: This study inputs the basic physical and chemical property parameters of warfarin sodium available at the present stage into GastroPlus™ software, and combined it with the Advanced Compartmental Absorption and Transit (ACAT
  • Using a Physiologically Based Pharmacokinetic Absorption Model to . . .
    Using a Physiologically Based Pharmacokinetic Absorption Model to Establish Dissolution Bioequivalence Safe Space for Oseltamivir in Adult and Pediatric Populations
  • Using a Physiologically Based Pharmacokinetic Absorption Model to . . .
    KEY WORDS: bioequivalence; dissolution; oseltamivir; pediatric; physiologically based pharmacokinetic absorption model INTRODUCTION To ensure therapeutic equivalency, generic drugs or new drug products from different manufacturing batches are required to have equivalent rate and extent of absorption to their reference
  • Real-world application of physiologically based pharmacokinetic models . . .
    The utility of physiologically based pharmacokinetic (PBPK) models in support of drug development has been well documented During the discovery stage, PBPK modeling has increasingly been applied for early risk assessment, prediction of human dose, toxicokinetic dose projection, and early formulation assessment
  • Physiologically Based Pharmacokinetics Modeling in Biopharmaceutics . . .
    Defining a BE safe space with physiologically based biopharmaceutics model (PBBM) allows the establishment of mechanistic in vitro and in vivo relationships (IVIVR) to better understand absorption mechanism and critical bioavailability attributes (CBA)
  • Physiologically based absorption modeling to predict the bioequivalence . . .
    Herein, we successfully developed a physiologically based absorption model for virtual BE simulations, which precisely predicts the BE of the apixaban test and reference formulations The modeling results confirm that the test and reference formulations were bioequivalent under both fasted and fed conditions, consistent with clinical studies





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